| A novel cell separation distance enhancer for inertial microfluidic devices |
| کد مقاله : 1145-FDC |
| نویسندگان |
|
یاسمن رخ زاد1، فرید روزی طلب1، محمد ضابطیان طرقی *2، روزبه عابدینی نسب1 1دانشگاه تربیت مدرس 2دانشگاه تربیت مدرس تهران |
| چکیده مقاله |
| The isolation of circulating tumor cells from whole blood is quite challenging due to their rarity in blood. Therefore, high-throughput microchannels with the highest efficiencies are needed. Inertial cell separation has been gaining great attention in recent years since it has been considered a label-free, high-throughput, and efficient method. Recently we have introduced a spiral microfluidic that separates particles of various sizes including 12μm,16μm and 18μm. However, obtaining high-throughput particle separation at high flow rates was challenging. To overcome this problem, in this study, we aimed to examine the separation of 16μm and 18μm particles by creating an outlet segment that handles high flow rates. Our objective was to enhance the separation distance to about 150μm while the flow rate is increased up to 2.4ml/min. In order to optimize the simulation results, the correlation between the expansion zone angle and the separation distance was thoroughly analyzed. This study demonstrated that by coupling different inertial zones, the separation distance could be increased. |
| کلیدواژه ها |
| high separation distance, inertial microfluidics, cell separation, hydrodynamic lift |
| وضعیت: پذیرفته شده |